Masayuki Amagai

Masayuki Amagai's picture
Masayuki
Amagai
Vice Dean, Keio University School of Medicine. Professor and Chair, Department of Dermatology, Keio University School of Medicine, Tokyo

2017 Rudi Cormane Lecture

Lecture Title: Cracking the Codes of Autoimmune and Allergic Skin Diseases 
Date: Thursday 28 September 2017, 15.50-16.20

Location: Europa Hall

Introduced by: Jonathan Barker

Profile

Dr Masayuki Amagai's clinical and research interests center on autoimmune and allergic skin diseases, skin barrier, and skin immunology. Specifically, he has been studying the pathophysiological mechanisms of pemphigus, the skin barrier and the homeostasis of stratum corneum and tight junctions, the impact of impaired skin barrier on skin microbiota and the onset of atopic dermatitis and other allergic disorders.

Selected Publications

Takahashi H, Kouno M, Nagao K, Wada N, Hata T, Nishimoto S, Iwakura Y, Yoshimura A, Yamada T, Kuwana M, Fujii H, Koyasu S, Amagai M. Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice. J Clin Invest 121 (9): 3677-3688, 2011.

Kubo A, Nagao K, Amagai M. Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases. J Clin Invest 122 (2): 440-447, 2012.

Nagao K, Kobayashi T, Moro K, Ohyama M, Adachi T, Kitashima DY, Ueha S, Horiuchi K, Tanizaki H, Kabashima K, Kubo A, Cho YH, Clausen BE, Matsushima K, Suematsu M, Furtado GC, Lira SA, Farber JM, Udey MC, Amagai M. Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin. Nat Immunol 13 (8): 744-752, 2012.

Sasaki T, Shiohama A, Kubo A, Kawasaki H, Ishida-Yamamoto A, Yamada T, Hachiya T, Shimizu A, Okano H, Kudoh J, Amagai M. A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis. J Allergy Clin Immunol 132 (5): 1111-1120, 2013

Yokouchi M, Atsugi T, Logtestijn MV, Tanaka RJ, Kajimura M, Suematsu M, Furuse M, Amagai M, Kubo A. Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape. eLife 5 e19593, 2016.
Amagai M. Modulating immunity to treat autoimmune disease. New Eng J Med, 375(15) 1487-1489, 2016.