Welcome to the 47th Annual ESDR Meeting 2017
Frontiers in Skin Biology & Dermatology
Lecture Title: Cell-Specific Functions of Epidermal Growth Factor Receptor (EGFR) Signaling in Inflammation and Cancer
Date: Thursday 28 September 2017
Tumors are increasingly being recognized as organs consisting of cancer cells and a variety of cells composing the ”tumor microenvironment” which include immune cells, vascular cells and fibroblasts. These stromal cells significantly contribute to malignant progression. Using the mouse as a model system her group aims to understand the role of Epidermal Growth Factor Receptor (EGFR) signaling in cancer cells, in tumor stromal cells and their complex interaction. The ultimate goal is to translate this knowledge to human patients to develop rational and effective therapies for the treatment of human cancer.
More information (external link)
Specific roles for dendritic cell subsets during initiation and progression of psoriasis.
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EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation.
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Epidermal EGFR controls cutaneous host defense and prevents inflammation.
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Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells.
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Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development.
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