Federica Sallusto

Federica Sallusto's picture
Federica
Sallusto
Group Leader, Institute for Research in Biomedicine, USI
Bellinzona, Switzerland

2017 Celgene ESDR Guest Lecture

Lecture Title:
 T cell Differentiation, Migration and Immune Regulation
Date: Friday 29 September 2017, 09.35-10.05
Room: Europa Hall

Introduced by: Michel Gilliet

Profile

Federica Sallusto received the degree of Doctor in Biology from the University of Rome in 1988, and performed postdoctoral work at the Istituto Superiore di Sanità in Rome and at the Basel Institute for Immunology, where she was a member from 11/1996 to 4/2000. She is currently Group leader of the Cellular Immunology Laboratory and Director of the Center of Medical Immunology at the Institute for Research in Biomedicine, Università della Svizzera italiana, in Bellinzona, and since February 2017 Professor of Medical Immunology at the ETH Zurich. Her studies in the human system revealed a differential expression of chemokine receptors in Th1 and Th2 cells and led to the characterization of “central memory” and “effector memory” T cells as memory subsets with distinct migratory capacity and effector function. Among her recent contributions are the discovery of Th22 cells as a distinct subset of skin-homing T cells, the identification of markers to identify human Th17 cells and the characterization of two distinct types of pathogen-specific Th17 cells with pro-inflammatory and regulatory properties. Her recent work demonstrated that the T cell response induced by pathogens or vaccines comprise not only clones polarized toward a single fate, but also clones whose progeny have acquired multiple fates, providing evidence of intraclonal functional heterogeneity in vivo. She also developed a high-throughput cellular screening method based on libraries of polyclonally expanded T cells and used this method to show that human T cells specific for Mycobacterium tuberculosis are largely contained in a non-conventional Th1 subset and to dissect the T cell response in Dengue and Zika infected individuals. She received the Pharmacia Allergy Research Foundation Award in 1999, the Behring Lecture Prize in 2009 and was elected member of the German Academy of Science Leopoldina in 2009 and of EMBO in 2011. In 2013-2015 she was President of the Swiss Society for Allergology and Immunology.

http://www.irb.usi.ch/cellular-immunology

Selected Publications

Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1beta production by myeloid cells
F. Ronchi, C. Basso, S. Preite, A. Reboldi, D. Baumjohann, L. Perlini, A. Lanzavecchia, F. Sallusto Nat Commun (2016) vol. 7 pp11541

T cell immunity. Functional heterogeneity of human memory CD4(+) T cell clones primed by pathogens or vaccines
S. Becattini, D. Latorre, F. Mele, M. Foglierini, C. De Gregorio, A. Cassotta, B. Fernandez, S. Kelderman, T. N. Schumacher, D. Corti, A. Lanzavecchia, F. Sallusto Science (2015) vol. 347 pp400-6

Proteome-wide analysis of HIV-specific naive and memory CD4+ T cells in unexposed blood donors
S. L. Campion, T. M. Brodie, W. Fischer, B. T. Korber, A. Rossetti, N. Goonetilleke, A. J. McMichael, F. Sallusto J Exp Med (2014) vol. 211 pp1273-80