European Epidermal Barrier Research Network (E2BRN)

Date: Wednesday 27 September 2017
Time: 11.00-18.45
Room: Mozart Hall 4+5

15th meeting of the European Epidermal Barrier Research Network


11.00-11.05 Opening
Johanna M. Brandner (Hamburg, Germany)
Session 1: Mendelian genetic disease and skin barrier
Chairs: Ryan O’Shaughnessy (UK), Florian Ehrlich (Austria)
11.05-11.30 One more step towards understanding sphingolipid metabolism and skin permeability barrier through the analysis of Pnpla1-deficient mice and PNPLA1-mutated patients suffering from Autosomal Recessive Congenital Ichthyosis (ARCI)
Nathalie Jonca (INSERM U1056 - Toulouse III University, France)
11.30-11.45 Evidence for a palmoplantar-specific role for microtubules
Helene Louis Dit Picard (Blizard Institute, Queen Mary University of London, UK)
11.45-12.00 In reconstructed human epidermis, peptidylarginine deiminase inhibitor Cl-amidine modulates cornification and keratinocyte autophagic flux
Michel Simon (UDEAR, INSERM-University of Toulouse, France)
12.00-12.15 Mutations in three genes encoding proteins involved in hair shaft formation cause uncombable hair syndrome
Buket Basmanav (Institute of Human Genetics, University of Bonn, Germany)
12.15-14.00 Lunch and Posters
Session 2: Skin Stress response
Chairs: Sandra Simoes (Lisbon), Guiseppe Percoco (France)
14.00-14.25 Control of mechanism of DC's cell death induced by chemical sensitizers
Saadia Kerdine-Römer (UMR-S 996, Faculté de Pharmacie, Université Paris-Sud, France)
14.25-14.40 Characterization of TSG-6 protein in healthy and inflammatory models of reconstructed human epidermis
Celine Evrard (URPhyM-NARILIS, University of Namur, Belgium)
14.40-14.55 Immortalized N/TERT keratinocytes: an excellent and versatile alternative for primary keratinocytes in experimental dermatological research
Jos P.H. Smits (Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands)

Characterization of xenobiotic metabolizing enzymes of a reconstructed human epidermal model, as part of the metabolism skin 
Hélène Duplan (Pierre Fabre Dermo-cosmétique, Toulouse, France)

15.10-15.35 Does stress help to brake the skin barrier? 
Eva Peters (Charité Universitaetsmedizin Berlin, Germany)
15.35-17.00 Coffee and Posters
Session 3: Skin Barrier Homeostasis
Chairs: Rosalind Hannen (UK), Jos P.H. Smits (The Netherlands)
17.00- 17.25 Stressed out keratinocytes
Rosalind Hannen (Queen Mary University of London Centre for Cell Biology and Cutaneous Research, Blizard Institute, UK)
17.25- 17.50 Persistent kallikrein5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity
Wei-Li Di (University College London, UK)
17.50-18.05 MiR-30a is an aged-related microRNA that impairs differentiation and induces apoptosis in human epidermis
Jerome Lamartine (LBTI UMR5305 CNRS/UCBLI, Lyon, France)
18.05-18.20 1-Deoxy-sphingosine, 3-Deoxy-sphingosine and N-Methyl-sphingosine Ceramides in Model Skin Membranes: Permeability and Biophysics
Andrej Kováčik (Skin Barrier Research Group, Charles University, Faculty of Pharmacy in Hradec Králové, Czech Republic)
18.20-18.35 Normalization of the stratum corneum lipids by targeting the liver X receptor in Human Skin Equivalents
R.J.W Helder (Drug delivery technology, LACDR Leiden University, The Netherlands)
18.35-18.45 Poster Prizes and Closing Remarks