European Epidermal Barrier Research Network (E2BRN)

Date: Wednesday 27 September 2017
Time: 11.00-18.45
Room: Mozart Hall 4+5

15th meeting of the European Epidermal Barrier Research Network


11.00-11.05 Opening
Johanna M. Brandner (Hamburg, Germany)
Session 1: Mendelian genetic disease and skin barrier
Chairs: Ryan O’Shaughnessy (UK), Florian Ehrlich (Austria)
11.05-11.30 One more step towards understanding sphingolipid metabolism and skin permeability barrier through the analysis of Pnpla1-deficient mice and PNPLA1-mutated patients suffering from Autosomal Recessive Congenital Ichthyosis (ARCI)
Nathalie Jonca (INSERM U1056 - Toulouse III University, France)
11.30-11.45 Evidence for a palmoplantar-specific role for microtubules
Helene Louis Dit Picard (Blizard Institute, Queen Mary University of London, UK)
11.45-12.00 In reconstructed human epidermis, peptidylarginine deiminase inhibitor Cl-amidine modulates cornification and keratinocyte autophagic flux
Laura Cau (UDEAR, INSERM-University of Toulouse, France)
12.00-12.15 Mutations in three genes encoding proteins involved in hair shaft formation cause uncombable hair syndrome
Buket Basmanav (Institute of Human Genetics, University of Bonn, Germany)
12.15-14.00 Lunch and Posters
Session 2: Skin Stress response
Chairs: Sandra Simoes (Lisbon), Guiseppe Percoco (France)
14.00-14.25 Control of mechanism of DC's cell death induced by chemical sensitizers
Saadia Kerdine-Römer (UMR-S 996, Faculté de Pharmacie, Université Paris-Sud, France)
14.25-14.50 Does stress help to brake the skin barrier?
Eva Peters (Charité Universitaetsmedizin Berlin, Germany)
14.50-15.05 Characterization of TSG-6 protein in healthy and inflammatory models of reconstructed human epidermis
Celine Evrard (URPhyM-NARILIS, University of Namur, Belgium)

Immortalized N/TERT keratinocytes: an excellent and versatile alternative for primary keratinocytes in experimental dermatological research
Jos P.H. Smits (Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands)

15.20-15.35 Characterization of xenobiotic metabolizing enzymes of a reconstructed human epidermal model, as part of the metabolism skin barrier
Daniel Bacqueville (Pierre Fabre Dermo-cosmétique, Toulouse, France)
15.35-17.00 Coffee and Posters
Session 3: Skin Barrier Homeostasis
Chairs: Rosalind Hannen (UK), Jos P.H. Smits (The Netherlands)
17.00- 17.25 Stressed out keratinocytes
Rosalind Hannen (Queen Mary University of London Centre for Cell Biology and Cutaneous Research, Blizard Institute, UK)
17.25- 17.50 Persistent kallikrein5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity
Wei-Li Di (University College London, UK)
17.50-18.05 MiR-30a is an aged-related microRNA that impairs differentiation and induces apoptosis in human epidermis
Jerome Lamartine (LBTI UMR5305 CNRS/UCBLI, Lyon, France)
18.05-18.20 1-Deoxy-sphingosine, 3-Deoxy-sphingosine and N-Methyl-sphingosine Ceramides in Model Skin Membranes: Permeability and Biophysics
Andrej Kováčik (Skin Barrier Research Group, Charles University, Faculty of Pharmacy in Hradec Králové, Czech Republic)
18.20-18.35 Normalization of the stratum corneum lipids by targeting the liver X receptor in Human Skin Equivalents
R.J.W Helder (Drug delivery technology, LACDR Leiden University, The Netherlands)
18.35-18.45 Poster Prizes and Closing Remarks